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These types of drugs can make a person feel detached from sensations and surroundings, as if they are floating outside their body.

Citing “questionable practice” regarding the prescription of ketamine, they point out that there is not enough evidence to prove that ketamine is safe, and that some studies supporting its use have not been sufficiently rigorous in terms of research ethics.

They call for open debate, more research, and for doctors to try all other options first, before prescribing ketamine.

Ketamine is a Class III controle substance. Prolonge use can cause dependence, tolerance, and withdrawal symptoms. Quitting can lead to depression, anxiety, insomnia, and flashbacks.

Chronic users are note to “binge” their ketamine use in an attempt to experience again the dissociative, euphoric effects of their early first use.

The complications of long-term use can be fatal.

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Some mental health experts advise caution where ketamine is concerned. “Although it can be an effective treatment for rapidly reducing symptoms of depression, we don’t yet know enough about its potential negative consequences.

The side effects of ketamine may include dissociative changes that are nearly always mild and transient, if they occur, as well as temporary elevation of heart rate and blood pressure often occur. These effects are usually well tolerated and usually don’t result in the discontinuation of treatment.¹

“During the infusion you can feel floaty or disconnected, but that typically lasts only about 45 minutes. Some people also feel a little bit of nausea” Dr. Levine says. “For those who benefit from ketamine the response tends to feel different than the emotional smoothing of SSRIs. People often describe a clarity of thinking, lifting of the weight of depression and an increased functional capacity which can take effect within the first few hours following treatment.”

But there’s another big use for ketamine. It’s found on dancefloors across North America and Europe every weekend, as thousands of ravers use it to get wobbly in the early hours of the morning. In 1999, the Drug Enforcement Administration deemed it a drug prone to abuse, and classified it as a Schedule III Controlled Substance.

If taking ketamine recreationally, how can people be as safe as possible?

The first thing is to do this with someone you trust—someone who could help you should you get into trouble. If you end up getting laryngospasm, you need someone OK with giving you mouth-to-mouth resuscitation.If you have an emergence reaction—where you wake up in an agitated state—you need someone there who you can trust to help bring you back down and get you to a safe place.

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People who are generally anxious shouldn’t use the drug at all. There’s also this concept of “setting the dream,” which I actually use in the emergency department. When I administer this drug in the hospital, I set people’s dreams. I tell them to think about a place where they really want to go on vacation, or ask them to think about the happiest times in their lives, and they start to think about that and have a “pleasant trip,” for lack of a better term. If someone comes into this already upset and agitated, there’s a much higher risk they’re going to have a bad reaction.